5061-5063
Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)
ARTICLES
5064-5071
2 Adrenoceptor Agonists as Potential Analgesic Agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles
5072-5076
Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques
5077-5094
Synthesis and SAR of Adatanserin: Novel Adamantyl Aryl- and Heteroarylpiperazines with Dual Serotonin 5-HT1A and 5-HT2 Activity as Potential Anxiolytic and Antidepressant Agents
5095-5099
Properties of Known Drugs. 2. Side Chains
5100-5109
Consensus Scoring: A Method for Obtaining Improved Hit Rates from Docking Databases of Three-Dimensional Structures into Proteins
5110-5119
Predicting Relative Binding Free Energies of Tacrine-Huperzine A Hybrids as Inhibitors of Acetylcholinesterase 
5120-5130
Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases
5131-5141
Synthesis, in Vitro Antiproliferative Activity, and DNA-Binding Properties of Hybrid Molecules Containing Pyrrolo[2,1-c][1,4]benzodiazepine and Minor-Groove-Binding Oligopyrrole Carriers
5142-5152
Binding Constants of Neuraminidase Inhibitors: An Investigation of the Linear Interaction Energy Method
5153-5159
Abasic Site Recognition in DNA as a New Strategy To Potentiate the Action of Anticancer Alkylating Drugs?
5160-5168
Quantitative Structure-Metabolism Relationships: Steric and Nonsteric Effects in the Enzymatic Hydrolysis of Noncongener Carboxylic Esters
5169-5180
Simple Linear QSAR Models Based on Quantum Similarity Measures
5181-5187
A Series of 6- and 7-Piperazinyl- and -Piperidinylmethylbenzoxazinones with Dopamine D4 Antagonist Activity: Discovery of a Potential Atypical Antipsychotic Agent
5188-5196
Potential Multifunctional Inhibitors of HIV-1 Reverse Transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] Heterodimers Modified in the Linker and in the Dideoxynucleoside Region
5197-5211
Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme
5212-5223
Design, Synthesis, and Biological Evaluation of Symmetrically and Unsymmetrically Substituted Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists
5224-5234
Analogues of Neuroactive Polyamine Wasp Toxins That Lack Inner Basic Sites Exhibit Enhanced Antagonism Toward a Muscle-Type Mammalian Nicotinic Acetylcholine Receptor
mgaard,
k,
5235-5240
New Quaternary Ammonium Oxicam Derivatives Targeted toward Cartilage: Synthesis, Pharmacokinetic Studies, and Antiinflammatory Potency
5241-5253
Discovery and Structure-Activity Relationships of Imidazole-Containing Tetrahydrobenzodiazepine Inhibitors of Farnesyltransferase
5254-5265
Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure-Activity Studies Leading to the Discovery of RWJ-53308
5266-5271
Vasorelaxation by New Hybrid Compounds Containing Dihydropyridine and Pinacidil-Like Moieties
BRIEF ARTICLES
5272-5276
N-Deacetyl-N-aminoacylthiocolchicine Derivatives: Synthesis and Biological Evaluation on MDR-Positive and MDR-Negative Human Cancer Cell Lines
5277-5283
Synthesis and Biological Evaluation of Novel Prodrugs of Anthracyclines for Selective Activation by the Tumor-Associated Protease Plasmin
BOOK REVIEWS
5284-5284
Rational Drug Design Edited by D. G. Truhlar, W. J. Howe, A. J. Hopfinger, J. Blaney, and R. Dammkoehler. Springer-Verlag, New York. 1999. xxii + 206 pp. 16 × 24 cm. ISBN 0-387-98753-3. $69.95.
5284-5285
Second Supplements to the Second Edition of Rodd's Chemistry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part G. Six-membered Heterocyclic Compounds with (a) a Single Nitrogen Atom in the Ring (cont'd.); Polycyclic Fused Ring Compounds, (b) an Atom of Phosphorus, Arsenic, Antimony or Bismuth. Alkaloids with a Six-Membered Heterocyclic Ring (Chapters 34-35 in this volume). Part H: Six-membered Fused-Ring Heterocyclic Compounds with a Single Atom in the Ring (cont'd.). Monocyclic Ring Compounds with Two Hetero-Atoms in the Ring from Group VIB, or One Each from Groups V and VIB. Alkaloids (cont'd.) Edited by M. Sainsbury. Elsevier, Amsterdam, 1998. xx + 650 pp. 15.5 × 23 cm. ISBN 0-444-82979-2. $402.50.
5285-5285
Protective Groups in Organic Synthesis. Third Edition By Theodora W. Greene and Peter G. M. Wuts. John Wiley & Sons, New York. 1999. xxi + 779 pp. 16 × 24 cm. ISBN 0-471-16019-9. $84.95.
5285-5286
Stereoselectivity in Synthesis By Tse-Lok Ho. John Wiley & Sons, New York. 1999. xv + 333 pp. 16 × 24.5 cm. ISBN 0471329223. $94.95.
5286-5287
Topics in Stereochemistry, Volume 22 Edited by Scott E. Denmark. Wiley Interscience, New York. 1999. xii + 314 pp. 16 × 23.5 cm. ISBN 0-471-25316-2. $95.00.
ADDITIONS AND CORRECTIONS
5288-5288
Synthesis, Pharmacological and Biophysical Characterization, and Membrane-Interaction QSAR Analysis of Cationic Amphiphilic Model Compounds.
5288-5288
Discovery and Structure-Activity Relationships of Imidazole-Containing Tetrahydrobenzodiazepine Inhibitors of Farnesyltransferase.